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The role of mitochondria in early-onset preeclampsia
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Placental mitochondrial dysfunction may play a role in the etiology of early-onset preeclampsia (EOPE). Mitochondrial function is impaired at term in placentas delivered from EOPE pregnancies, ...
Tracing cat domestication through population genetics and capturing genotype-by environment interactions in US beef cattle genomic predictions
(University of Missouri--Columbia, 2022)
Cat domestication initiated as a symbiotic relationship between wildcats and the peoples of developing agrarian societies in the Fertile Crescent. To refine the sites of cat domestication, over 1,000 random-bred cats of ...
Involvement of aberrant chromosome architecture and locus-specific vulnerability to DNA methylation epimutations in bovine large offspring syndrome
(University of Missouri--Columbia, 2022)
Large/abnormal offspring syndrome (LOS/AOS) and Beckwith-Wiedemann syndrome (BWS) are similar congenital overgrowth syndromes which occur naturally in ruminants and humans, respectively. The incidence of these syndromes ...
An examination of influenza immunity in pigs and their role in assessing antiviral therapies for humans
(University of Missouri--Columbia, 2022)
The lung is dynamic barrier organ with a complex cell population. Pulmonary immune cells must balance an effective and tolerogenic response to keep homeostasis. Due to numerous similarities to the human respiratory system, ...